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Targeted Therapies

The goal of chemotherapy is to kill cancer cells that grow and divide rapidly. It also affects normal cells that are also fast growing (e.g., cells in the skin, lining of the digestive tract, hair follicles), which can cause unwanted side effects. To reduce damage to normal cells, newer drugs called targeted therapies interfere with the ways that cancer cells function. These processes include:

  • New blood vessel formation (angiogenesis)
    • Cancer cells rely on new blood vessels to supply them with oxygen and nutrients. Drugs that block angiogenesis starve cells of their blood supply, which helps to slow or stop tumor growth. These drugs also seem to make traditional chemotherapies more effective.
  • Stimulation from growth signals
    • Cancer cells may rely on signals that tell them to grow or divide uncontrollably. Drugs that block these signals may help to slow or stop tumor growth.

Most targeted therapies are either monoclonal antibodies or small-molecule drugs.

Monoclonal antibodies are proteins that attach to substances called receptors on the surface of the cell and block signals that tell the cell what to do. They can also be used alone to target defects in the cancer cells or make the cancer cells more receptive to the body’s immune system.  Monoclonal antibodies can also carry other drugs or substances directly to a tumor.

  • Bevacizumab (Avastin) was approved in 2004 for the treatment of NSCLC that is not squamous cell carcinoma. It is frequently given with traditional chemotherapy. Avastin should not be used to treat squamous cell lung cancer because in clinical trials, those with squamous cell had many more life-threatening and fatal side effects from the drug. For more information, see the Avastin website. 

Small-molecule drugs can get inside the cell and stop the cell from functioning normally, which usually causes it to die. Tyrosine kinase inhibitors (TKIs) are small-molecule drugs that interfere with cell communication and growth. More TKIs are being studied for use in lung cancer but the following is a list of those approved to treat the disease. .

  • Erlotinib (Tarceva) was first approved in 2004 for the treatment of advanced-stage NSCLC after the cancer has spread after initial chemotherapy (as 2nd or 3rd line treatment) and is also approved for use as a maintenance therapy in certain cases of locally advanced NSCLC. In May 2013, Tarceva was approved for initial (1st line) treatment for advanced NSCLC when the cancer has the epidermal growth factor receptor (EGFR) mutation with certain properties, as detected by an FDA-approved test. For more information, see the Tarceva website. 
  • Afatinib (Gilotrif) was approved in July 2013 for people people with late stage (NSCLC) when the cancer has the epidermal growth factor receptor (EGFR) gene mutation with certain properties, as detected by an FDA-approved test.  
  • Crizotinib (Xalkori) was approved in September 2011. It targets the EML4-ALK (echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase) rearrangement. The EML4-ALK rearrangement is found in 2-7% of people with NSCLC, primarily those diagnosed with adenocarcinoma and is more common in men and never smokers. For those patients with the mutation, Xalkori has shown dramatic results. For more information, see the Xalkori website. 
  • Ceritinib (Zykadia) was approved in April 2014. It also targets the EML4-ALK rearrangement and is approved only for those previously treated with Xalkori. 
  • Gefitinib (Iressa) was approved in the US in May 2003 but removed in June 2005 after studies showed it did not help the majority of people to live longer. Like Tarceva, Iressa targets the EGFR mutation. Iressa is still available to patients who received benefit from the drug at the time the US approval was removed. It remains an approved treatment for lung cancer in over 30 countries and continues to be studied in clinical trials in the US.